Medical Journal News

New England Journal of Medicine, Volume 392, Issue 12, Page 1245-1246, March 27, 2025.

New England Journal of Medicine, Volume 392, Issue 12, Page 1243-1245, March 27, 2025.

New England Journal of Medicine, Volume 392, Issue 12, Page 1241-1242, March 27, 2025.

New England Journal of Medicine, Volume 392, Issue 12, Page 1232-1233, March 27, 2025.

New England Journal of Medicine, Volume 392, Issue 12, Page 1230-1232, March 27, 2025.

New England Journal of Medicine, Volume 392, Issue 12, Page 1215-1215, March 27, 2025.

New England Journal of Medicine, Volume 392, Issue 12, Page 1216-1227, March 27, 2025.

New England Journal of Medicine, Volume 392, Issue 12, Page 1234-1236, March 27, 2025.

New England Journal of Medicine, Ahead of Print.

Rising cases of tuberculosis (TB) and measles and an intense influenza and respiratory syncytial virus (RSV) season were seen in England in 2024-25, reiterating the fact that “we cannot be complacent,” the outgoing head of the UK Health Security Agency (UKHSA) has said.The agency’s first report on infectious diseases looks at data from 2023 to early 2025 and acknowledges that social mixing, international travel, migration, and vaccine hesitancy following the covid-19 pandemic have contributed to these patterns of infection.1Provisional data for 2024 show that there were 600 new cases of TB in England in 2024, 13% more than in 2023. This followed an 11% increase in cases in 2023, with 4855 notifications of the disease compared with 4380 in 2022.If cases of TB continue to increase on their current trajectory the UK would lose its World Health Organisation low incidence status, warned Jenny Harries, chief executive of the UKHSA, at...

Decades of progress in improving childhood survival are being put at risk because of major cuts to aid funding, the United Nations has warned.In a report1 published on 25 March the UN found that the number of children dying globally before their 5th birthday has more than halved from 10.1m in 2000 to 4.8m in 2023. Stillbirths have declined modestly, from 2.9m in 2000 to 1.9m in 2021.2But it warned that these gains are now under threat as major aid donors such as the US have announced funding cuts. Earlier this month the Trump administration permanently cancelled funding for nearly 10 000 projects supporting global health and development, equating to a cut of nearly $60bn in aid spending.3 US cuts to foreign aid have already closed vital child malnutrition services in war torn Sudan.4World Health Organization director general Tedros Adhanom Ghebreyesus said, “In the face of global funding cuts, there...

The chancellor of the exchequer, Rachel Reeves, will set out the UK government’s spending plans in her spring statement on 26 March.1 The consultative green paper, Pathways to Work,2 has already outlined plans to cut several billion from the welfare budget, with the aim of saving £5bn by 2029-30.3 The plans include stricter criteria for personal independence payments (PIP) for people with disabilities; halving incapacity benefit payments under Universal Credit for new claimants; and restriction of incapacity benefit top-ups to those aged 23 years and older.Ministers have argued there is a “moral case” for these cuts, and that “people that can work [should be] able to work.”3 However, the chancellor’s approach is unlikely to achieve this goal for two key reasons. First, high rates of economic inactivity in the UK reflect its almost unique failure among industrialised countries to recover population health after the pandemic,456 which came on top of...

In the UK more than 3 in every 1000 people are taking glucagon-like peptide-1 (GLP-1) agonist drugs, says Kevin McCarroll, consultant physician and geriatrician at St James Hospital, Dublin.1 Depending on the region, 77-179 in 100 000 people are using the leading GLP-1 drug semaglutide (Ozempic for type 2 diabetes, Wegovy for obesity), he says.1 And these are just the official prescribing figures—anecdotal evidence suggests many are purchasing the drugs from unofficial sources.Growing evidence of the drugs’ efficacy for weight loss2 is fuelling demand worldwide. The number of patients in the US approved for GLP-1 agonist treatment for obesity rose from 190 000 a month in 2021 to 1.8 million in 2024.3 Analysis of the US market shows that 5.2% of women and 4.2% of men with obesity are being prescribed the drugs, although access varies.“The global supply shortage seen in 2024 was at least partly because of a surge...

by Hiroki Shinmura, Youhei Tsunoda, Takashi Matsushima, Ryuhei Kurashina, Asako Watanabe, Eika Harigane, Nozomi Ouchi, Shunji Suzuki

Background

In Japan, the lateral position method is known as a postural therapy for breech presentation wherein the mother lies down in lateral position according to the orientation of the fetal back. Few studies have formally tested lateral position management for breech presentation, and no method exists to prevent breech recurrence after cephalic version. We hypothesized that postural management comprising a combination of opposite-side lateral position for breech presentation and same-side lateral position after cephalic version demonstrates a clinically relevant effect size on breech presentation.

Methods and findings

We conducted a stratified, open-label randomized controlled trial at an academic hospital in Kawasaki, Japan. A total of 200 women diagnosed with breech presentation between 28 +  0 and 30 +  0 gestational weeks were randomized to postural management (n =  100) or control (no intervention, n =  100) group. The intervention was instruction every 2 weeks on lying in the lateral position on the opposite-side of fetal back for breech presentation and on the same-side of fetal back for head-first presentation. The primary outcome was the rate of fetuses in breech presentation at 37 weeks of gestation, and the secondary outcomes were cesarean delivery, cesarean delivery for breech presentation, head presentation 2, 4, and 6 weeks later, breech presentation recurrence, and adverse events. Breech presentation rate at 37 gestational weeks was 11% in the intervention group, using the combination of the opposite-side and same-side lateral positions, compared with 19% in the control group. However, we found no statistical significance in the intention-to-treat analysis (11% [11/100] versus 19% [19/100]; relative risk, 0.58 [95% CI, 0.29 to 1.15]; p =  0.11). In the control group, 23 participants (23%) unknowingly took the same posture as the intervention group, and the prespecified per-protocol analysis excluding crossover found the same direction of effect but with statistical significance. In the intention-to-treat analysis, the intervention group had a higher cephalic version rate 2 weeks after the instruction (69% [69/100] versus 54% [54/100]; relative risk, 0.67 [95% CI, 0.47 to 0.96]; p =  0.029), and lower breech presentation recurrence rates (2% [2/91] versus 10% [9/88]; relative risk, 0.22 [95% CI, 0.048 to 0.97]; p =  0.031) than the control group. Regarding adverse events in the intervention group, three participants experienced discomfort and one participant complained of pain in the lateral abdomen; these symptoms resolved spontaneously.

Conclusions

For breech presentation at the beginning of the third trimester, providing postural therapy instruction on opposite-side lateral positioning and same-side lateral positioning was associated with 8% reduction of breech fetuses at 37 gestational weeks compared with the control group, but this primary endpoint did not reach statistical significance. Regarding the secondary endpoints, the intervention group showed a significantly higher rate of cephalic version after 2 weeks and lower rate of breech recurrence. The direction of the effect of postural therapy based on fetal back position on breech presentation was promising, and further research to validate this approach, with consideration for unplanned participant crossover, may be warranted.

Trial registration

UMIN Clinical Trials Registry (UMIN000043613, https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049800).

Medical students from across the UK rallied outside the Department for Education on 19 March to demand adequate financial support.BMA representatives from the Medical Students Committee delivered a letter to Bridget Phillipson, the secretary of state for education, asking the government to “ensure that both undergraduate and graduate students are eligible for the full Student Finance England maintenance loan provision for all years of study,” as well as improving access to funding through the NHS bursary, “including improving the claims process and exploring new sources of funding.”Medical students stop being solely funded by Student Finance England in their fifth year when maintenance loans fall from a maximum of £10 277 to £2670 an academic year. This is then topped up with the NHS bursary of £1020 and a means tested grant of up to £2696 for those outside of London and £3255 for those in London. An additional £86 a...

Lawyers for families whose babies the nurse Lucy Letby was convicted of killing or assaulting have cast doubt on the findings by an international panel of experts which appear to exonerate her.1The 14 strong panel revealed its conclusion that the deaths were attributable to natural causes or poor medical care at the Countess of Chester Hospital, where Letby worked, at a press conference organised by her barrister, Mark McDonald, last month.2 Letby is serving 15 life terms after being convicted of murdering seven babies and attempting to murder seven others between June 2015 and June 2016.3 McDonald is asking the Criminal Cases Review Commission to send the case back to the Court of Appeal, after Letby’s previous attempts were turned down.In written submissions to the Thirlwall inquiry, the legal team representing several babies’ families, headed by Richard Baker KC, noted that the panel, assembled by the retired Canadian neonatologist Shoo...

The government has been urged to remove the financial barriers to doctors taking on additional work after a BMA survey showed that many consultants and GPs have cut their hours in the past year because of pension tax rules.The BMA’s poll of more than 5000 senior doctors found that many have reduced their work commitments to such a degree that if replicated across the wider workforce it would equate to the loss of around 5400 full time consultants. The BMA highlighted that this is almost 10% of capacity that could be offered to the NHS in England to tackle waiting lists this year. For GP partners, it estimates that the reduction in hours represents a potential loss of around four million appointments.The long standing problem is related to the tapered annual allowance (AA), introduced in 2016, which imposes a limit on how much senior doctors can put into their pension...

The UK has confirmed a case of H5N1 influenza of avian origin in a sheep in Yorkshire, in a world first.The infection in the animal was identified through routine and repeated milk testing, which was enforced after avian influenza was confirmed in captive birds on the same premises. The sheep has now been “humanely culled” and no other cases of avian influenza have been detected in the remaining sheep, the Department for Environment, Food, and Rural Affairs and the Animal and Plant Health Agency have said.“While this is the first time this virus has been reported in a sheep, it is not the first time influenza of avian origin has been detected in livestock in other countries,” the announcement said. “There is no evidence to suggest an increased risk to the nation’s livestock.”In January the UK confirmed a human case of influenza A (H5N1) in a person in the West...

The growing number of medical students put on a “placeholder” list after applying for foundation year training raises serious concerns about the capacity and foresight of the UK Foundation Programme Office (UKFPO). In 2024, more than a thousand medical school graduates were left without allocated foundation year training posts and faced a prolonged period of uncertainty while emergency posts were created.1 This has left graduates unable to plan the next steps of their careers and personal lives. Early reports suggest that this year hundreds of students have again been given a placeholder allocation.2The shortage of foundation training posts is indicative of a growing problem, as the number of students graduating from UK medical schools is expected to continue rising.3 This is the harbinger of an emerging workforce crisis. Unless there is an adequately planned, sustained expansion in the number of foundation training posts available in the UK, the placeholder list...

A growing tendency in official data to ask a person for their gender identity rather than their sex is having serious consequences in some areas of healthcare such as missed cancer screenings and mistakes in blood testing.An independent, government commissioned report1 into the collection of accurate data and statistics on biological sex concluded that public bodies should collect distinct data on both sex and gender identity to ensure that nationally held data are accurate and clear.The report, published by the Department for Science, Innovation, and Technology, sets out a timeline of how survey data have been collected since the 1960s. It shows how the word “gender” started to replace “sex” in some data collection in the 1990s, and in some survey data, gender was defined as “sex” while in others gender was defined as “identity.”The review authors found that from around 2015 the word “gender” started to be understood in...